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Manfred Uhr

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Manfred Uhr, PD Dr. med. Dr. rer.nat.

Research group leader
Head of the neurological outpatient clinic
Head of the neurophysiological and clinical chemistry unit
Senior neurologist
Text Link Intern RG Uhr: Pharmacokinetics and CSF Analysis
Text Link Intern Neurologische Ambulanz
Text Link Intern Neurophysiologie
Phone: 089/30622-651
Fax: 089/30622-310
Email: uhr[a]mpipsykl.mpg.de
   
CV:
Born in Bremen, Germany. University studies: biology and medicine (Georg August University of Göttingen). From 1990 to 1996 assistant doctor in the neurological department and the neurochemical laboratory of the University of Göttingen. Since 1996 working at the Max Planck Institute of Psychiatry, since 1997 Head of the neurochemical laboratory and the research group "Pharmacokinetics and CSF Analysis", since 1999 Assistant Medical Director and Head of the neurological outpatient clinic and the department of clinical neurophysiology. Text Link Intern CV (pdf)
Further activities:
  • Vice chairman of the Deutsche Gesellschaft für Liquoranalytik und Klinische Neurochemie (DGLN)
Selected publications:
Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Salyakina D, Bettecken T, Pütz B, Binder EB, Müller-Myhsok B, Holsboer F (2008) Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron, 57:203-209

Uhr M, Grauer MT, Holsboer F (2003) Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry, 54:840-846

Müller MB, Keck ME, Binder EB, Kresse AE, Hagemeyer TP, Landgraf R, Holsboer F, Uhr M (2003) ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology 28:1991-1999

Uhr M, Holsboer F, Müller MB (2002) Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins. J Neuroendocrinology 14:753-759

Uhr M, Steckler T, Yassouridis A, Holsboer F (2000) Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption. Neuoropsychopharmacology 22:380-387