Effects of chronic stress in genetically modified mouse lines with depression-like neuroendocrine and behavioural phenotypes

At the Institute, numerous genetically modified mouse lines are available, which can be tested as models for psychiatric diseases, see RG Jan Deussing. Apart from the characterization of these mouse lines under basal and acute stress conditions it is important to study how these mouse models react towards the risk factor chronic stress. In some mouse lines one would expect a protective effect, whereas others might be especially vulnerable. We will expose these mouse models to chronic stress using different stress paradigms during ontogeny or adulthood. Thereby, especially neuroendocrine, behavioural, cognitive, electrophysiological and structural changes are to be examined.

Research group involved:

Tallie Z. Baram, University California, USA

Günther Schütz, DKFZ, Heidelberg, Germany

Publications:

Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice C, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart M, Müller MB, and Schmidt MV; Forebrain CRF1 Modulates Early Life Stress-Programmed Cognitive Deficits; The Journal of Neuroscience (2011), in press

Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, Schmidt MV; The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress; Neuropharmacology (2011), in press

Touma C, Gassen NC, Herrmann L, Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox M, Schmidt U, Rein T; FKBP5 shapes stress responsiveness: Modulation of neuroendocrine reactivity and coping behavior; Biological Psychiatry (2011), in press

Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, and Schmidt MV; Forebrain CRHR1 Deficiency Attenuates Chronic Stress-Induced Cognitive Deficits and Dendritic Remodeling; Neurobiology of Disease (2011), 42(3):300-10

Wagner KV, Wang XD, Liebl C, Scharf SH, Müller MB, Schmidt MV; Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress; Psychoneuroendocrinology (2011), 36(4):579-87

Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, de Angelis MH, Holsboer F, Wurst W; Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2; The Journal of Neuroscience (2010), 30(27):9103-16

Schmidt MV, Sterlemann V, Wagner K, Niederleitner B, Ganea K, Liebl C, Deussing JM, Berger S, Schütz G, Holsboer F and Müller MB; Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences; Endocrinology (2009), 150(6):2709-16

Schmidt MV, Liebl C, Sterlemann V, Ganea K, Hartmann J, Harbich D, Alam S and Müller MB; Neuropeptide Y mediates the initial hypothalamic-pituitary-adrenal response to maternal separation in the neonatal mouse; Journal of Endocrinology (2008) 197(2):421-7

Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Müller MB, de Kloet ER; Differential disinhibition of the neonatal hypothalamic-pituitary-adrenal axis in brain specific CRH receptor 1 knock out mice; European Journal of Neuroscience (2006), 24(8):2291-8