Sleep in patients with endocrine disorders
The investigation of sleep EEG in patients with endocrine disorders helps to understand the role of hormones in sleep regulation since elevated or reduced hormone secretion in these disorders results in sleep-EEG changes. Most endocrine disorders go ahead with impaired sleep quality. As exception we found a selective increase of slow wave sleep in patients with prolactinoma in comparison to normal control subjects.
Fig. 1. Sleep pattern in one male 25 years old patient with prolactinoma (A), and in one matched control (B), (Frieboes RM, Murck H, Stalla GK, Antonijevic IA, Steiger A: Enhanced slow wave sleep in patients with prolactinoma, Journal of Clinical Endocrinology and Metabolism,. Vol. 83, No. 8, 1998, Fig. 1, 2709. Copyright 1998, The Endocrine Society).
Patients with acquired growth hormone deficiency received chronic growth hormone substitution. No changes of sleep EEG were found during this therapy. Whereas these patients frequently suffer from fatigue, no enhanced daytime sleepiness was found in the multiple sleep-latency test.
Research groups involved:
RG Axel Steiger: Michael Kluge, Petra Schüssler
RG Günter Stalla: Harald Schneider, Caroline Sievers
Frieboes R.M., Murck H., Stalla G.K., Antonijevic I.A., Steiger A. (1998) Enhanced slow wave sleep in patients with prolactinoma. J. Clin. Endocrinol. Metab., 83, 2706-2710
Schneider H.J., Oertel H., Murck H., Pollmächer T., Stalla G.K., Steiger A. (2005) Night steep EEG and daytime steep propensity in adult hypopituitary patients with growth hormone deficiency before and after six months of growth hormone replacement. Psychoneuroendocrinology, 30, 29-37