Publikationen der AG Ising seit 2004
Klengel T, Heck A, Pfister H, Brückl T, Hennings JM, Menke A, Czamara D, Müller-Myhsok B, Ising M (in press) Somatization in major depression - clinical features and genetic associations. Acta Psychiatrica Scandinavica
Seemüller F, Riedel M, Obermeier M, Schennach-Wolff R, Spellmann I, Meyer S, Bauer M, Adli M, Kronmüller K, Ising M, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Möller HJ (in press) The validity of self-rated psychotic symptoms in depressed inpatients. European Psychiatry
Sievers C & Sämann PG, Pfister H, Dimopoulou C, Czisch M, Roemmler J, Schopohl J, Stalla GK, Zihl J (in press) Cognitive function in acromegaly: description and brain volumetric correlates. Pituitary
Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionesci IA, Heinzmann J-M, Knapman A, Siebertz A, Depping A-M, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T (in press) FKBP5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biological Psychiatry
Zimmermann P, Brückl T, Nocon A, Pfister H, Binder EB, Uhr M, Lieb R, Moffit TE, Caspi A, Holsboer F, Ising M (in press) Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. The American Journal of Psychiatry
Dunlop BW, Betancourt Y, Binder EB, Heim C, Holsboer F, Ising M, McKenzie M, Mletzko T, Pfister H, Nemeroff CB, Craighead WE, Mayberg HS (2011) Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder. Journal of Psychiatric Research 45:24-28
Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, Heck A, Pfister H, Zimmermann P, Lieb R, Putz B, Uhr M, Weber P, Deussing JM, Gonik M, Bunck M, Kessler MS, Frank E, Hohoff C, Domschke K, Krakowitzky P, Maier W, Bandelow B, Jacob C, Deckert J, Schreiber S, Strohmaier J, Nothen M, Cichon S, Rietschel M, Bettecken T, Keck ME, Landgraf R, Müller-Myhsok B, Holsboer F, Binder EB (2011) TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry 16:647-663
Heck A, Pfister H, Czamara D, Müller-Myhsok B, Putz B, Lucae S, Hennings J, Ising M (2011) Evidence for associations between MDGA2 polymorphisms and harm avoidance - replication and extension of a genome-wide association finding. Psychiatric Genetics 21:257-260
Hoch, E., Zimmermann, P., Henker, J., Rohrbacher, H., Noack, R., Bühringer, G. & Wittchen, H.-U. (2011). Modulare Therapie von Cannabisstörungen: Das CANDIS-Programm. Göttingen: Hogrefe.
Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nothen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (2011) The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression. Neuron 70:252-265
Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, Weber F (2011) More CLEC16A gene variants associated with multiple sclerosis. Acta Neurologica Scandinavica 123:400-406
Sarapas C, Cai G, Bierer LM, Golier JA, Galea S, Ising M, Rein T, Schmeidler J, Müller-Myhsok B, Uhr M, Holsboer F, Buxbaum JD, Yehuda R (2011) Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Disease Markers 30:101-110
Schosser A, Butler AW, Ising M, Perroud N, Uher R, Ng MY, Cohen-Woods S, Craddock N, Owen MJ, Korszun A, Jones L, Jones I, Gill M, Rice JP, Maier W, Mors O, Rietschel M, Lucae S, Binder EB, Preisig M, Perry J, Tozzi F, Muglia P, Aitchison KJ, Breen G, Craig IW, Farmer AE, Müller-Myhsok B, McGuffin P, Lewis CM (2010) Genomewide association scan of suicidal thoughts and behaviour in major depression. PLoS One 6:e20690
Hennings JM, Ising M, Grautoff S, Himmerich H, Pollmacher T, Schaaf L (2010) Glucose tolerance in depressed inpatients, under treatment with mirtazapine and in healthy controls. Experimental and Clinical Endocrinology & Diabetes 118:98-100
Holsboer F, Ising M (2010) Stress hormone regulation: biological role and translation into therapy. Annual Review of Psychology 61:81-109
Horstmann S, Lucae S, Menke A, Hennings JM, Ising M, Roeske D, Müller-Myhsok B, Holsboer F, Binder EB (2010) Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment. Neuropsychopharmacology 35:727-740
Kloiber S, Kohli MA, Brueckl T, Ripke S, Ising M, Uhr M, Menke A, Unschuld PG, Horstmann S, Salyakina D, Müller-Myhsok B, Binder EB, Holsboer F, Lucae S (2010) Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular Psychiatry 15:736-747
Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJ, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL, Farmer A, McGuffin P, Day R, Matthews K, Bakke P, Gulsvik A, Lucae S, Ising M, Brueckl T, Horstmann S et al (2010) Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics 42:436-440
Lucae S, Ising M, Horstmann S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Domschke K (2010) HTR2A gene variation is involved in antidepressant treatment response. European Neuropsychopharmacol 20:65-68
Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Roeske D, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, Weber F (2010) Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. Journal of Neuroimmunology 227:162-166
Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB (2010) Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology 35:1583-1592
Yehuda R, Flory JD, Pratchett LC, Buxbaum J, Ising M, Holsboer F (2010) Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD. Psychopharmacology 212:405-417
Adli M, Bschor T, Bauer M, Lucka C, Lewitzka U, Ising M, Uhr M, Müller-Oerlinghausen B, Baethge C (2009). Long-term outcome after lithium augmentation in unipolar depression: focus on HPA system activity. Neuropsychobiology 60:23-30
Binder EB, Künzel HE, Nickel T, Kern N, Pfennig A, Majer M, Uhr M, Ising M, Holsboer F (2009) HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not female depressed patients. Psychoneuroendocrinology 34:99-109
Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M (2009) Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients. American Journal of Medicine Genetic Part B: Neuropsychiatric Genetics 150B:104-114
Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Roeske D, Puetz B, Müller-Myhsok B, Uhr M, Holsboer F, Ising M (2009) Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on Novelty Seeking. Genes, Brain and Behavior 8:464-472
Hennings JM, Owashi T, Binder EB, Horstmann S, Menke A, Kloiber S, Dose T, Wollweber B, Spieler D, Messer T, Lutz R, Künzel H, Bierner T, Pollmächer T, Pfister H, Nickel T, Sonntag A, Uhr M, Ising M, Holsboer F, Lucae S (2009) Clinical characteristics and treatment outcome in a representative sample of depressed inpatients – Findings from the Munich Antidepressant Response Signature (MARS) project. J Psychiatr Res 43:215-229
Horstmann S, Dose T, Lucae S, Kloiber S, Menke A, Hennings J, Spieler D, Uhr M, Holsboer F, Ising M (2009) Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action. Psychoneuroendocrinology 34:238-248
Indlekofer F, Piechatzek M, Daamen M, Glasmacher C, Lieb R, Pfister H, Tucha O, Lange KW, Wittchen HU, Schütz CG (2009) Reduced memory and attention performance in a population-based sample of young adults with a moderate lifetime use of cannabis, ecstasy and alcohol. Journal of Psychopharmacology. Vol.23(5):495-509
Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, Kohli MA, Hennings JM, Horstmann S, Kloiber S, Menke A, Bondy B, Rupprecht R, Domschke K, Braune BT, Arolt V, Rush JA, Holsboer F, Müller-Myhsok B (2009) A genome-wide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Archives of General Psychiatry 66:966-975
Künzel HE, Ackl N, Hatzinger M, Held K, Holsboer-Trachsler E, Ising M, Kaschka W, Kasper S, Konstantinidis A, Sonntag A, Uhr M, Yassouridis A, Holsboer F, Steiger A (2009) Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol – A double-blind multicenter trial. Journal of Psychiatric Research 43:702-710
Piechatzek M, Indlekofer F, Daamen M, Glasmacher C, Lieb R, Pfister H, Tucha O, Lange KW, Wittchen HU, Schütz CG (2009) Is moderate substance use associated with altered executive functioning in a population-based sample of young adults?. Human Psychopharmacology. 24(8):650-665
Reppermund S, Ising M, Lucae S, Zihl J (2009) Cognitive impairment in unipolar depression is persistent and non-specific: Further evidence for the final common pathway disorder hypothesis. Psychological Medicine 39:603-614
Sievers C, Dimopoulou C, Pfister H, Lieb R, Steffin B, Roemmler J, Schopohl J, Mueller M, Schneider HJ, Ising M, Wittchen HU, Stalla GK (2009). Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients. Clin Endocrinol 71:691-701
Sievers C, Ising M, Pfister H, Dimopoulou C, Schneider HJ, Römmler J, Schopohl J, Stalla GK (2009) Personality in patients with pituitary adenomas is characterized by anxiety-related traits: comparison of 70 acromegalic patients with non-functioning pituitary adenomas and age- and gender-matched controls. European Journal of Endocrinology 160:367-373
Sievers C, Sämann PG, Dose T, Dimopoulou C, Spieler D, Roemmler J, Schopohl J, Mueller M, Schneider HJ, Czisch M, Pfister H, Stalla GK (2009) Macroscopic brain architecture changes and white matter pathology in acromegaly: a clinicoradiological study. Pituitary. 12(3):177-185
Thoeringer CK, Ripke S, Unschuld PG, Lucae S, Ising M, Bettecken T, Uhr M, Keck ME, Müller-Myhsok B, Holsboer F, Binder EB, Erhardt A (2009) The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders. Journal of Neural Transmission 116:649-657
Unschuld PG, Ising M, Specht M, Erhardt A, Ripke S, Heck A, Kloiber S, Straub V, Brueckl T, Müller-Myhsok B, Holsboer F, Binder EB (2009). Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. Am J Med Genet B Neuropsychiatr Genet 150B:1100-1109
Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, Rein T, Schmeidler J, Müller-Myhsok B, Holsboer F, Buxbaum JD (2009). Gene expression patterns associated with PTSD following exposure to the World Trade Center attacks. Biol Psychiatry 66:708-711
Zimmermann P, Brückl T, Nocon A, Pfister H, Lieb R, Wittchen H-U, Holsboer F, Angst J (2009) Heterogeneity of DSM-IV Major Depressive Disorder as a Consequence of Subthreshold Bipolarity. Archives of General Psychiatry 66:1341-1352
Angst J, Zimmermann P (2008). The manic wing of the bipolar spectrum. European Psychiatric Review, 1(1):19-21.
Erhardt A, Lucae S, Kern N, Unschuld PG, Ising M, Lieb R, Uhr M, Hohoff C, Deckert J, Bandelow B, Maier W, Binder EB, Müller-Myshok B, Keck ME, Holsboer F (2008) Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks. Molecular Psychiatry 13:242-243
Felber W, Winiecki P, Schmidtke A, Ising M, Bronisch T (2008) Midlife-Suizide in Progression? Anstieg der Suizidalität bei 45- bis 54-jährigen in den USA. Suizidprophylaxe 35:97-101
Friess E, Modell S, Brunner H, Tagaya H, Lauer CJ, Holsboer F, Ising M (2008) The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects. European Archives of Psychiatry and Clinical Neuroscience 258:285-291
Friess E, Schmid D, Modell S, Brunner H, Lauer CJ, Holsboer F, Ising M (2008) Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders. Journal of Psychiatric Research 42:1154-1162
Heck A, Lieb R, Unschuld PG, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M (2008) Evidence for associations between PDE4D polymorphisms and a subtype of neuroticism. Molecular Psychiatry 13:831-832
Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S, Gedrich K, Kloiber S, Lucae S, Ising M, Uhr M, Holsboer F, Pollmächer T (2008) Depression, comorbidities and the TNF-alpha system. European Psychiatry 23:421-429
Holsboer F, Ising M (2008) Central CRH system in depression and anxiety – Evidence from clinical studies with CRH(1) receptor antagonists. European Journal of Pharmacology 583:350-357
Ising M, Depping AM, Siebertz A, Lucae S, Unschuld PG, Kloiber S, Horstmann S, Uhr M, Müller-Myhsok B, Holsboer F (2008) Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. European Journal of Neuroscience 28:389-398
Ising M, Heck A. Genetik der Stressreaktion (2008) In: Janke W, Schmidt-Daffy M, Debus G, editors. Experimentelle Emotionspsychologie. Lengerich: Pabst Science Publishers p. 481-500
Ising M, Holsboer F. Biomarkers for the development of antidepressant and anxiolytic drugs. In: Turck CW, editor. Biomarkers for psychiatric disorders. New York, NY: Springer, 2008. p. 427-443
Keck ME, Kern N, Erhardt A, Unschuld PG, Ising M, Salyakina D, Müller MB, Knorr CC, Lieb R, Hohoff C, Krakowitzky P, Maier W, Bandelow B, Fritze J, Deckert J, Holsboer F, Müller-Myhsok B, Binder EB (2008) Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. American Journal of Medicine enetics Part B: Neuropsychiatric Genetics 147B:1196-1204
Lewitzka U, Müller-Oerlinghausen B, Felber W, Brunner J, Hawellek B, Rujescu D, Ising M, Lauterbach E, Broocks A, Bondy B, Rao ML, Frahnert C, Heuser I, Hohagen F, Maier W, Bronisch T (2008) Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients? Acta Psychiatr Scand 117:41-49
Menke A, Lucae S, Kloiber S, Horstmann S, Bettecken T, Uhr M, Ripke S, Ising M, Müller-Myhsok B, Holsboer F, Binder EB (2008) Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation. Am JPsychiatry 165:917-918.
Nocon A, Wittchen HU, Beesdo K, Brückl T, Höfler M, Pfister H, Zimmermann P, Lieb R (2008) Differential familial liability of panic disorders and agoraphobia. Depression and Anxiety 25(5):422-434
Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Müller-Myhsopk B, Holsboer F (2008) Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron 57:203-209
Unschuld PG, Ising M, Erhardt A, Lucae S, Kohli M, Kloiber S, Salyakina D, Thöringer CK, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME (2008) Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. J Affective Disorders 105:177-184
Weber F, Fontaine B, Cournu-Rebeix I, Kroner A, Knop M, Lutz S, Müller-Sarnowski F, Uhr M, Bettecken T, Kohli M, Ripke S, Ising M, Rieckmann P, Brassat D, Semana G, Babron MC, Mrejen S, Gout C, Lyon-Caen O, Yaouanq j, Edan G, Clanet M, Holsboer F, Clerget-Darpoux F, Müller-Myhsok B (2008) IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes and Immunity 9:259-263
Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peclau I, Eisensehr I, Illig T, Wichmann HE, Pfister H, Golic J, Bettecken T, Pütz B, Holsboer F, Meitinger T, Müller-Myhsok B (2008) Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. Movement Disorders 33:350-358
Wittchen HU, Nocon A, Beesdo K, Pine DS, Höfler M, Lieb R, Gloster A (2008) Agoraphobia and panic: Prospective-longitudinal relations suggest a rethinking of diagnostic concepts. Psychotherapy and Psychosomatics 77(3):147-157
Zimmermann R, Brückl T, Lieb R, Nocon A, Ising M, Beesdo K, Wittchen HU (2008) The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up. Biological Psychiatry 63:406-414
Brückl TM, Wittchen HU, Höfler M, Pfister H, Schneider S, Lieb R (2007) Childhood separation anxiety and the risk of subsequent psychopathology: Results from a community study. Psychotherapy Psychosomatics 76:47-56
Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, Lieb R, Uhr M, Binder EB, Keck ME, Müller-Myhsok B, Holsboer F (2007) Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. J Affect Disord 101:159-168
Himmerich H, Zimmermann P, Ising M, Kloiber S, Lucae S, Künzel HE, Binder EB, Holsboer F, Uhr M (2007) changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment. Neuropsychobiology 55:28-35
Höfler M, Brückl T, Bittner A, Lieb R (2007) Visualizing multivariate dependencies with association chain graphs. Methodology 3:24-34
Ising M (2007) Bringing basic and clinical research together to an integrated understanding of psychiatric disorders. J Psychiatr Res 41:1-2
Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, Künzel HE, Pfennig A, Uhr M, Holsboer (2007) Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression – A potential biomarker? Biol Psychiatry 62:47-54
Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM, Holsboer F, Grigoriadis DE (2007) High-affinity CRF (1) receptor antagonist NBI-34041: Preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmagology 32:1941-1949
Kloiber S, Ising M, Reppermund S, Horstmann S, Dose T, Majer M, Zihl J, Pfister H, Unschuld PG, Holsboer F, Lucae S (2007) Overweight and obesity affect treatment response in major depression. Biol Psychiatry 62:321-326
Nocon A (2007) Angst und Depression bei Jugendlichen. Häufigkeit, gemeinsames Auftreten und Verlauf. Saarbrücken: VDM-Verlag Dr. Müller
Ströhle A, Höfler M, Pfister H, Müller AG, Hoyer J, Wittchen HU, Lieb R,(2007) Physical activity and prevalence and incidence of mental disorders in adolescents and young adults. Psychological Medicine. 37(11):1657-1666
Unschuld PG, Ising M, Erhard A, Lucae S, Kloiber S, Kohli M, Salyakina D, Welt T, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME (2007) Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder. Am J Med Genet B Neuropsychiatr Genet 144:424-429
Thoeringer CK, Binder EB, Salyakina D, Erhardt A, Ising M, Unschuld PB, Kern N, Lucae S, Brückl TM, Müller MB, Fuchs B, Pütz B, Lieb R, Uhr M, Holsboer F, Müller-Myhsok B, Keck ME (2007) Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks. J Psychiatr Res 41:579-584
Wittchen HU, Fröhlich C, Behrendt S, Günther A, Rehm J, Zimmermann P, Lieb R, Perkonigg A (2007) Cannabis use and cannabis use disorders and their relationship to mental disorders: A 10-year-prospektive-longitudinal community study in adolescents. Drug Alcohol Dependence 88:60-70
Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, Notdurfter C, Holsboer F, Müller-Myhsok B, Möller, HJ, Rupprecht R, Bondy B (2006) Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry 11:1003-1015
Brunner J, Bronisch T, Pfister H, Jacobi F, Höfler M, Wittchen HU (2006) High cholesterol, triglycerides and body-mass index in suicide attempters. Arch Suicide Res 10:1-9
Christl, B, Wittchen HU, Pfister H, Lieb R, Bronisch T (2006) The accuracy of prevalence estimations for suicide attempts. How reliably do adolescents and young adults report their suicide attempts? Arch Suicide Res 10:253-263
Erhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Putz B, Uhr M, Binder EB, Holsboer F, Keck ME (2006) Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder. Neuropsychopharmacology 31:2515-2522
Friess E, Kuempfel T, Modell S, Winkelmann J, Holsboer F, Ising M, Trenkwalder C (2006) Paroxetine treatment improves motor symptoms in patients with multiple system atrophy. Parkinsonism Relat Disord 12:432-437
Himmerich H, Binder EB, Künzel HE, Schuld A, Lucae S, Uhr M, Pollmächer T, Holsboer F, Ising M (2006) Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis. Biol Psychiatry 60:882-888
Ising M (2006) Moderating factors in psychiatric disorders – Essential to understanding the diversity of phenotypes. J Psychiatr Res 40:381-382
Ising M, Holsboer F (2006) Genetics of stress response and stress-related disorders. Dialogues Clin Neurosci 8:433-444
Ising M, Weyers P, Reuter M, Janke W (2006) Comparing two approaches for the assessment of coping: II. Differences in stability in time. J Individual Differences 27:15-19
Lauterbach E, Brunner J, Hawellek B, Lewitzka U, Ising M, Bondy B, Rao ML, Frahnert C, Rujescu D, Müller-Oerlinghausen B, Schley J, Heuser I, Maier W, Hohagen F, Felber W, Bronisch T (2006) Platelet 5-HT(2A) receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behaviour. J Affect Disord 91:57-62
Lucae S, Salyakina D, Barden N, Harvey M, Gagne B, Labbe M, Binder EB, Uhr M, Paez-Pereda M, Sillaber I, Ising M, Brückl T, Lieb R, Holsboer F, Müller-Myhsok B (2006) P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum Mol Genet 15:2439-2445
Nocon A, Wittchen HU, Pfister H, Zimmermann P, Lieb R (2006). Dependence symptoms in young cannabis users? A prospective epidemiological study. J Psychiatr Res 40:394-403
Perkonigg A, Pfister H, Höfler M, Fröhlich C, Zimmermann P, Lieb R, Wittchen HU (2006) Substance use and substance use disorders in a community sample of adolescents and young adults: Incidence, age effects and patterns of use. European Addict Res 12:187-196
Perkonigg A, Settele A, Pfister H, Höfler M, Fröhlich C, Zimmermann P, Lieb R, Wittchen HU (2006) Where have they been? Service use of regular substance users with and without abuse and dependence. Soc Psychiatry Psychiatric Epidemiology 41:470-479
Post A, Ackl N, Rücker M, Schreiber Y, Binder EB, Ising M, Sonntag A, Holsboer F, Almeida OF (2006) Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression. Biol Psychiatry 59:858-862
Schmidt DA, Wichniak A, Uhr M, Ising M, Brunner H, Held K, Weikel JC, Sonntag A, Steiger A (2006) Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazepine. Neuropsychopharmacology 31:832-844
Schüssler P, Uhr M, Ising M, Weikel JC, Schmid DA, Held K, Mathias S, Steiger A (2006) Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology 31:915-923
Van Rossum EFC, Binder EB, Majer M, Koper JW, Ising M, Modell S, Salyakina D, Lamberts SWJ, Holsboer F (2006) Polymorphisms of the glucocorticoid receptor gene and major depression. Biological Psychiatry 59;681-688
Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer DP (2005) Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neurosci Lett 384:23-8
Brunner J, Bronisch T, Uhr M, Ising M, Binder E, Holsboer F, Turck CW (2005) Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters. Europ Arch Psychiatr Clin Neuroscience 255:438-440
Höfler M, Brückl T, Lieb R, Wittchen HU (2005) Calculating control variables with age at onset data to adjust for conditions prior to exposure. Soc Psychiatr Psychiatric Epidemiol 40:731-736
Höfler M, Pfister H, Lieb R, Wittchen HU (2005) The use of weights to account for non-participation. Soc Psychiatr Psychiatric Epidemiol 40:291-299
Ising M (2005) Disturbed stress hormone regulation in depression – critical gene and environment effects. Neurotransmitter 16:63-67
Ising M, Janke W (2005) Paired samples CFA for the multicariate detection of change in small samples. Psychol Science 47:446-452
Ising M, Künzel HE, Binder EB, Nickel T, Modell S, Holsboer F (2005) The combined dexamethasone/CRH test as a potential surrogate marker in depression. Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93
Ising M, Lauer CJ, Holsboer, F, Modell S (2005) The Munich vulnerability study on affective disorders: Premorbid neuroendocrine profile of affected high-risk probands. J Psychiatr Res 39:21-28
Künzel HE, Ising M, Zobel AW, Nickel T, Ackl N, Sonntag A, Holsboer F, Uhr M (2005) Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression. J Psychiatr Res 39:173-177
Modell S, Ising M, Holsboer F, Lauer CJ (2005) The Munich vulnerability study on affective disorders: Premorbid polysomnographic profile of affected high-risk probands. Biol Psychiatry 58:694-699
Perkonigg A, Pfister H, Stein MB, Höfler M, Lieb R, Maercker A, Wittchen HU (2005) Longitudinal course of PTSD and PTSD-symptoms in a community sample of adolescents and young adults. Am J Psychiatry 162:1320-1327
Perkonigg A, Yonkers KA, Pfister H, Lieb R, Wittchen HU (2005) Risk factors for premenstrual dysphoric disorder – the role of traumatic events and PTSD. Am J Psychiatry 162:1320-1327
Pfennig A, Künzel HE, Kern N, Ising M, Majer M, Fuchs B, Ernst G, Holsboer F, Binder EB (2005) Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression. Biol Psychiatry 57:336-42
Schmid DA, Held K, Ising M, Uhr M, Weikel JC, Steiger A (2005) Ghrelin stimulates appetite, imagination of food, GH, ACTH and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology 30:1187-92
Schüssel P, Uhr M, Ising M, Schmid DA, Weikel JC, Steiger A (2005) Nocturnal ghrelin levels – relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol – and gender differences. J Sleep Res 14:329-336
Weyers P, Ising M, Janke W (2005) Effects of imagined stress intensity on responses in a stress coping inventory. Anxiety Stress Coping 18:117-130
Weyers P, Ising M, Reuter M, Janke W (2005) Comparing two approaches for the assessment of coping: I. Psychometric properties and intercorrelations. J Individual Differences 26:207-212
Winkelmann J, Prager M, Lieb R, Pfister H, Spiegel B, Wittchen HU, Holsboer F, Trenkwalder C, Ströhle A (2005) “Anxietas Tibiarum”. Depression and anxiety disorders in patients with restless legs syndrome. Neurology 252:67-71
Zimmermann P, Wittchen HU, Waszak F, Nocon A, Höfler M, Lieb R (2005) Pathways into ecstasy use: The role of prior cannabis and ecstasy availability. Drug and Alcohol Dependence 79:331-341
Binder EB, Salyakina D, Lichtner P, Wochnik G, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Köhnlein O, Dabitz H, Brückl T, Müller N, Pfister H, Lieb R, Müller JC, Lohmussar E, Strom T, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Müller-Myhsok B (2004) Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature Genetics 12:1319-1325
Bschor B, Ising M, Bauer M, Lewitzka U, Skerstupeit M, Müller-Oerlinghausen B (2004) Time experience and time judgment in major depression, mania and healthy subjects. A controlled study of 93 subjects. Acta Psychiatr Scand 109:222-229
Goodwin RD, Lieb R, Höfler M, Pfister H, Bittner A, Beesdo K, Wittchen HU (2004) Panic attack as a risk factor for severe psychopathology among young adults. Am J Psychiatr 161:2207-2214
Hatzinger M, Hemmeter UM, Brand S, Ising M, Holsboer-Trachsler E (2004) Electroencephalographic (EEG) sleep profiles in treatment course and long-term outcome of major depression: association with DEDX/CRH test response. J Psychiatr Res 38:453-465
Held K, Künzel H, Ising M, Schmid DA, Zobel A, Murck H, Holsboer F, Steiger A (2004) Treatment with the CRH 1 receptor antagonist R121919 improves sleep-EEG in patients with depression. J Psychiatr Res 38:129-136
Ising M, Dietl T, Dirlich G, Vogl L, Pollmächer T, Nickel T, Sonntag A, Strian F, Lechner C, Lauer CJ, Modell S (2004) Long-latency somatosensory potentials in high risk probands for affective disorders. J Psychiatr Res 38:219-221
Ising M, Lauer CJ, Holsboer F, Modell S (2004) The Munich vulnerability study on affective disorders: Premorbid psychometric profile of affected individuals. Acta Psychiatr Scand 109:332-338
Jacobi F, Wittchen HU, Hölting C, Höfler M, Pfister H, Müller N, Lieb R (2004) Prevalence, comorbidity and correlates of mental disorders in the general population: Results from the German National Health Interview and Examination Survey (GHS). Psychol Med 34:597-611
Majer M, Ising M, Künzel HE, Binder EB, Holsboer F, Modell, S et al. (2004) Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders. Psychol Medicine 34:1453-1463
Perkonigg A, Pfister H, Lieb R, Bühringer G, Wittchen HU (2004) Problematischer Konsum illegaler Substanzen, Hilfesuchverhalten und Versorgungskapazität in einer Region. Suchtmedizin in Forschung und Praxis 6:22-31
Perkonigg A, Wittchen HU, Zimmermann P, Nocon A, Settele A, Spiegel B, Bühringer G, Lieb R (2004). Grundlagen und Forschungsstrategien regionaler Bedarfs- und Allokationsforschung am Beispiel des ASAT-F1-Projektes. Suchtmedizin in Forschung und Praxis 6:14-21
Perkonigg A, Yonkers KA, Pfister H, Lieb R, Wittchen HU (2004) Risk factors for premenstrual dysphoric disorder – the role of traumatic events and PTSD. J Clin Psychiatr 65:1314-1322
Sharma AM, Wittchen HU, Kirch W, Pittrow D, Ritz E, Goke B, Lehnert H, Tschope D, Krause P, Höfler M, Pfister H, Bramlage P, Unger T, HYDRA Study Group (2004) High prevalence and poor control of hypertension in primary care: cross-sectional study. Journal of Hypertension. 22(3):479-486
Steckelings UM, Stoppelhaar M, Sharma AM, Wittchen HU, Krause P, Küpper B, Kirch W, Pittrow D, Ritz E, Göke B, Lehnert H, Tschöpe D, Höfler M, Pfister H, Unger T, HYDRA Study Group (2004) HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patients. Blood Press 13(2):80-88
Wetter TC , Ising M (2004) Association between polymorphism within the promoter region of the serotonin transporter gene and treatment response in depression-further evidence but still controversial issues. Sleep Med 5:93-95
Wichniak A, Brunner H, Ising M, Pedrosal Gil F, Holsboer F, Friess E (2004) Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression. Psychoneuroendocrinology 29:1101-1108
Zimmermann P, Mühlig S, Sonntag D, Bühringer G, Wittchen HU (2004) Review on psychotherapeutic interventions for cannabis disorders. Sucht 50:334-342
Top
Drucken